Kinjiro "Jiro" Sakamachi has gynophobia (fear of women) that stems from his (pro-wrestling I think) mom and sister practicing on him ever since he could walk. This phobia manifests into a nosebleed whenever he is touched by women. His sister Kureha wakes him up with painful wrestling moves and at school he avoids women like the plague - because to him they are the plague. Now the tale really kicks into overdrive when he meets Subaru Konoe - a butler to one of the school's most popular girls - Kanade Suzutsuki. Now the thing about Subaru - he's actually a she.
Now to be perfectly clear, I don't really like harem animes. I find them quite repetitive and just one big bowl of fanservice consisting of boob grabbing, panty watching etc. Not into that sort of thing. It has to have a really cool twist or plot to grab my attention. Actually, it has to have a cool twist or plot to KEEP my attention. I also have a soft spot for really funny stuff. I'm a big fan of Negima (one male teacher teaching at an all-girls school) and Infinite Stratos (male student attending all female school with mecha like exoskeletons). The former is very funny to watch and the second utilizes several ideas and turns them into hilarious hijinks plots. That's about as far as my harem tastes go, so I am really hard to please when it comes to this particular genre.